A 70-year-old man presents with progressive shortness of breath and intermittent dull left-sided chest discomfort for several months.
He denies fever or acute chest pain but reports a 20-year history of rheumatoid arthritis with longstanding pleural thickening seen on previous imaging.
On examination, he is comfortable at rest, afebrile, and saturating 97 % on air.
There is stony dullness and reduced breath sounds over the left hemithorax.
Thoracic ultrasound confirms a large chronic pleural effusion with thickened pleural rind.
Diagnostic aspiration yields opaque, milky fluid.
Pleural fluid analysis:
Triglyceride: 0.8 mmol/L
Cholesterol: 6.2 mmol/L
Protein: 50 g/L
Cytology: negative for malignancy
Cholesterol crystals present
According to the BTS Pleural Disease Guideline (2023), what is the most likely diagnosis