A 41-year-old man attends the Emergency Department with recurrent burning epigastric discomfort. He is clinically stable, has no haematemesis, melaena, weight loss, dysphagia, persistent vomiting, or iron-deficiency anaemia. He is discharged with safety-netting and advised to follow up with his GP. Subsequent testing confirms Helicobacter pylori infection. He has no penicillin allergy and has not recently received macrolide or nitroimidazole antibiotics.

According to NICE guidance, which is the most appropriate first-line eradication regimen?